During the Fear Itself storyline, She-Hulk joins with Howard the Duck, Nighthawk and the Frankenstein Monster to form a four-person team called the Fearsome Four to stop the Man-Thing from its destructive path. They later discover a plot by Psycho-Man to use the Man-Thing's volatile empathy to create a weapon.
A group formed by circumstance when Man-Thing found himself driven to an uncontrollable rage, caused by the immense levels of fear generated by the Serpent's hammer-wielders across the world. Facing various alternate universe heroes and the Psycho-Man, brought to Earth by the Man-Thing's connection to the Nexus of All Realities, the four were eventually able to confront their own fears and calm the Man-Thing, bringing an end to his rampage and saving the world, before going their separate ways.